14 Ağustos 2012 Salı

Hemoglobin Around The Globe

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Commonly abbreviated as Hb, Hemoglobin, or Heamoglobin, is the iron containing oxygen in our red blood cells which transport metalloproteins. All mammals on earth have hemoglobin, as it is a necessary function in the blood. It contains globin, apoprotien, and four heme groups (organic molecules with one atom of iron attached to each).The gene for the hemoglobin protien can sometimes mutate. This occurence results in one or more of many diseases, but most commonly turns into Thalassemia or Sickle-cell disease.

Heme groups are located in each sub-unit of a hemoglobin [http://www.hemoglobinspot.com] molecule. A heme group consists of a single iron atom, held in a heterocyclic ring, commonly known as a "porphyrin". Oxygen binding takes place in this iron atom. The one iron atom binds itself equally to all four nitrogens in the center of the heterocyclic ring, which lies on one plane. In addition, two bonds perpendicular to the plane on each side, are sometimes formed with the iron to produce the fifth and sixth positions.

The name hemoglobin comes from "heme" and "globin". Globin is a generic term used for a globular protein. Since any single subunit of hemoglobin is made of a heme imbedded in a globular protein, the name makes perfect sense. There are many heme containing hemoglobins and proteins. Hemoglobin A is the most commonly known.

In adults, the most common hemoglobin is a tetramer (hemoglobin containing 4 subunit proteins) called hemoglobin A. The subunits are similar in structure, and approximatly the same size. Each subunits molecular weight is about 16,000 daltons, for a total combined molecular weight in the tetramer of approximatly 64,000 daltons. A single heme is contained in each subunit of hemoglobin, so that the overall binding capacity of human adults hemoglobin for oxygen is four oxygen molecules.

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Tyler Brooker is the owner and operator of The Hemoglobin Index [http://www.hemoglobinspot.com] - [http://www.hemoglobinspot.com], which is the best site on the internet for all hemoglobin related information.

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Type 2 Diabetes - Hemoglobin A1c: A Useful Test for Diabetes Control

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It is widely acknowledged good Type 2 diabetes care rests on a foundation of patient knowledge. Knowing what care you should receive is vital, since not even all doctors are aware of the guidelines set by the American Diabetes Association. A survey published in the Annals of Internal Medicine in the year 2002, estimated only 30 percent of people with diabetes had a hemoglobin A1c, (HbA1c), test during the previous year. This is a crucial test which should be given to all people with diabetes at least twice a year.

Are you a diabetic? Does your doctor advise you to have your hemoglobin A1c taken every three months? Are you wondering why you still need to have your hemoglobin A1c examined when you already check your blood sugar level regularly? What is Hemoglobin A1c? What is the importance of having this laboratory test?

The hemoglobin A1c is the stable glucose portion on the beta-chain of the hemoglobin, the oxygen transporters of red blood cells. It is formed by an irreversible reaction when red blood cells become exposed to glucose. And because it is irreversible, no diabetic can ever alter or manipulate the results of his or her hemoglobin A1c. Therefore, it is the single best test to monitor a diabetic's overall blood sugar control for the past three months.

Hemoglobin A1c values are a strong indicator for the development of long-term complications of Type 2 diabetes. In fact, the risk for diabetic retinopathy, neuropathy, and diabetic nephropathy can be easily projected by just looking at the previous HbA1c results. Cardiovascular disease, another complication of diabetes, is also another risk seen with the rising values of HbA1c through smoking, hypertension and increased blood lipid levels can also trigger its development.

What are the usual indications for hemoglobin A1c monitoring? Everyone with diabetes who needs constant monitoring and tight blood sugar control need to have their HbA1c level checked once every three to six months. However, it can be performed more often in cases where treatment management is changed rapidly or drastically. As well, anyone who is known to be at high risk for developing Type 2 diabetes should also undergo this laboratory test according to the Johns Hopkins Point-of-Care Information Technology Center.

How do you interpret your HbA1c results? The HbA1c percentage is the average blood sugar control for the past three months. It accounts for all the highs and lows of blood sugar spikes and troughs, this test is a better indicator of your overall status than the fasting blood sugar test. Non-diabetics usually have a HbA1c value of 4 to 6 percent. People who have a result of 8 percent have poor blood sugar control while those with a reading higher than 10 percent have uncontrolled Type 2 diabetes. Diabetes is considered controlled when the reading is less than 6.5 to 7 percent.

What are the limitations in HbA1c monitoring? Anything that can possibly decrease the survival rate of red blood cells also affects this value. Therefore, people with hemolytic anemia, a condition where individual red blood cells burst, have lower HbA1c values. In contrast to this, an increase in the lifespan of red blood cells, such as in aplastic anemia can also increase the hemoglobin A1c value independent of the blood sugar level.

A report published in the Lancet, May 2009 reported that diabetic patients who lowered their hemoglobin A1c value by just 1 percent over 5 years can reduce the overall rate of heart attacks by 17 percent and fatal and non-fatal heart attacks by 15 percent. It seems worthwhile to me in order to savor life longer!

To discover answers to questions you may be asking yourself about Type 2 Diabetes, click on this link... Natural Diabetes Treatments

Clicking on this link will help you to learn more about Type 2 Diabetes Solutions ... Beverleigh Piepers RN... the Diabetes Detective.

Beverleigh Piepers is the author of this article. This article can be used for reprint on your website provided all the links in the article are complete and active. Copyright (c) 2010 - All Rights Reserved Worldwide

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What Is Hemoglobin And How Does It Affect Your Health?

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Hemoglobin in essence is what transports oxygen from the lungs to the other cells in the entire body. Oxygen is the most basic element of human life and its need in the body is very important. There are many health conditions that in particular have to pay very close attention to measuring the amount of oxygen that is actually in their hemoglobin. Such conditions as asthma, COPD, and other respiratory conditions require that there be a constant monitoring of the oxygen levels in order to ensure that the body is getting enough. In the medical field the measure of the amount of O2 in the blood is referred to as SpO2 or also known as blood oxygen saturation. It is this blood oxygen saturation that those that have various kinds of respiratory conditions need to keep an eye on and to closely monitor. The primary medical device that is used to measure the SpO2 is a pulse oximeter.

The way that hemoglobin can affect your health directly is when not enough of O2 is being transported to the cells in your body and as a result you will begin to have various detrimental health affects that are not so easily fixed. If for example you have asthma then one of the biggest concerns is always the fact that you need to keep a very close eye on your oxygen levels in order to make sure that you prevent an asthma attack. When there is not enough of it in your system then you run the risk of an attack which can be very dangerous to your health. One way to measure this and to prevent an attack is to closely monitor it with the use of a pulse oximeter. What the device does in fact is that it uses special infrared technology to measure the percentage in the bloodstream.

The latest can be found at http://www.pulseoximetersupply.com of pulse oximeter technology.

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The Hand: Anatomy and Medical Issues

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Basic Anatomy
The hand has a very complex anatomy. There is a fine balance between the flexor tendon system, principally from muscles in the forearm that bend the fingers into a grasp, the extensor muscle tendon system from the extensor muscle side of the forearm, and the intrinsic muscles in the palm and proximal portion of the hand.

The tendons that originate from the muscles in the forearm all pass through tunnels. On the extensor side of the wrist, the extensor retinaculum is a thick sheath of fibrous tissue which keeps the tendons from bowstringing, and allows the tendons to function effectively in extending the hand. The forearm muscles that generate the flexor tendons pass through the carpal tunnel, and then in the hand pass through multiple tunnels, which are easily described best as located at every place in the palm where there is a skin crease, in the middle palm and at the base of each phalangeal joint.

Every finger including the thumb, has nerves, arteries, and veins on each side of the digit. This supports the circulation and the sensation to those fingers. Knowing where the neurovascular is would allow at the time of laceration or injury the physician to know the risk to the nerve or the circulation that any particular injury has caused.

A finger can usually get by with one artery and one vein, because the circulation from the opposite side of the finger will usually be sufficient and cross over and fill the need. But if the nerve is lacerated one must expect loss of sensation distal to that laceration. The most important sensation of the fingers to preserve or attempt to restore by surgical repair would be both sides of the thumb, the radial side of the index and long finger, which is necessary for effective sensory pinch, and the ulnar side of the ring and little finger, which commonly are in contact with the surface. It is not that the other areas of sensation are not useful, just not as important.

Laceration / Amputation
Lacerations of flexor tendons can be serious injuries and may need special skills of a surgeon and then special physical therapy for the hand, usually also with a hand therapy specialist. Extensor tendon lacerations and repairs are more "forgiving', and are commonly repaired, even in the emergency room, followed by appropriate splinting and then appropriate therapy.

Amputation of fingertips or phalanges beyond the mid of the middle finger are seldom "reimplanted". They are usually treated with a primary wound closure, or treated "expectantly" with continued wound care of the amputation site (which is left initially open), but does require continued wound care for 4-6 weeks. This is a technique that has the advantage of preserving the maximum length possible of the digit that has been partially amputated. This technique is time consuming and does require a very cooperative patient, but will usually offer a benefit.

Reimplantation means re-attaching the amputated part, finger, or other part of an extremity to the remainder of that extremity or hand. It is usually done by a very specialized surgical team at a referral center. Everything must be ideal. The surgery takes many hours and the recovery takes many months. The results are seldom perfect and almost always a compromise after significant trauma and investment of a great amount of time, cost, and effort. This effort is usually considered primarily for a dominant hand, a thumb, an index finger particularly in a younger injured patient where activity function and job function makes the effort and the commitment reasonable. Reconstruction must be considered an exceptional and not a common procedure, and the choice for reconstructing the amputation site, as opposed to reimplantation, is generally most preferable in a working person and early return to function is highly desirable.

Fractures of the Hand
Fractures of the hand usually require an attempt to achieve close to anatomic or anatomic realignment. The type of reduction can be closed, or non-surgical, just by manipulating the fracture externally. It can surgically open. There can be multiple types of fixation devices used internally surgically, screws, and plates; externally there can be pins applied through the skin and casts and external fixators. It remains important to allow the hand, wrist, and forearm to regain function and use as early as possible, but safely.

Fractures do need to be assessed, however, in 3 planes: the front plane, the side plane, and also the rotational plane. If a fracture heals with a rotational deformity of the metacarpal or finger, it will underlap or overlap the adjacent fingers. It is an issue like this that will commonly force one toward a more aggressive and even surgical approach in treating a hand fracture.

An exception to the above is known as treating the "boxer's fracture." This is a fracture of the distal end of the fifth metacarpal commonly angulated 20-45 degrees usually occurring either in a fight or hitting a hard surface, such as a wall with one's hand. A study done over 30 years ago demonstrated that reducing a boxer's fracture surgically does not give as good a result as just splinting the fracture, as long as it does not exceed an acceptable degree of flexion deformity, with that splint maintained for approximately 3 weeks. Then early function is attempted, and early movement encouraged. This noninvasive technique and treatment has given very good results with very few complaints, very little stiffness issues whereas the surgical approach had far less desirable results, though surgery may be considered for an exceptional case.

The phalanges are notorious for having hyperextension and twisting injuries, and it is common to see minor chip fractures about the joints of the fingers. Though these fractures seem minor, they are always accompanied by damage and injury to the ligaments, the capsules of the joint, or the tendon attachments to the joint. These injuries should be evaluated and a treatment plan established by a skilled practitioner. They should not be ignored or just treated with extension splinting or buddy taping. Dislocations of the joints of the digits are common in sports, and they, too, need to be assessed clinically and radiologically to be certain that there is no more serious injury that needs to be addressed.

Fractures of the distal joint are commonly caused by having a ball hit awkwardly off the extended finger. This may cause either a fracture of the tuft of the phalanx, or can cause a hyperflexion of the distal joint tearing the extensor tendon, usually with a flake of bone off its insertion site. This is known as a mallet finger, and can usually be treated simply after an x-ray to demonstrate that there is no deformity of the joint by a hyperextension splint that needs to be worn until there is evidence of healing. Occasionally surgery is necessary to repair the tendon and the bony fragment into its normal site. Epiphyseal fractures through the growth plate in children need special attention to minimize deformity, which sometimes cannot be avoided, depending on the damage to the epiphysis (growth plate) and should not be ignored by the parents.

Diagnostic Tools
The mainstay of diagnosis is the physical clinical exam by a physician skilled and knowledgeable in hand anatomy and function. X-rays are the primary line of diagnostic study. As most x-rays are now principally digital, they can be reviewed by a consulting physician on an almost-immediate basis. By accessing the films online, there is little excuse for having potential complex injuries not identified as the injured party passes through the emergency room. Computerized x-ray scanning such as CT scan is generally used in the hand solely to identify complex fractures of the carpal bones and/or the wrist in anticipation of surgical reconstruction.

MRI, magnetic resonance imaging is helpful in several ways: one is identifying soft tissue injury, as the MRI is more specific for soft tissue injury than a CT scan or x-ray; another is evaluating the rare risk of tumor or deep infection; also MRI is useful for identifying the subtle circulatory changes and the response of the bone that has been injured; and, it can be a useful diagnostic tool for the complicated wrist or hand problem, acute or chronic, when diagnosis seems very elusive.

Medical-Legal Considerations
Clearly, the hand functions with its tendons, its nerves, its vascular circulation, its multiple carpal bones, metacarpals, and phalanges as a very complex part of our body, needing particular care. That care should include proper diagnosis in an early and timely way and skilled treatment for an ideal result.

Dr. John Toton is an Orthopedic Expert for American Medical Forensic Specialists. Visit AMFS to get more information on Medical Expert Witness articles and opinions.

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Bone Cancer Metastasis

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An estimated 60% to 84% of patients with cancer develop bone metastasis. Of these 70% experience pain syndrome which is difficult to manage, of which 50% die without adequate pain relief with a poor quality of life. It is therefore necessary to have accessible and effective medications for the management of this condition. One of the most common pain syndromes in patients with advanced cancer is bone metastasis. This is difficult to manage and control in clinical practice. Currently, scientific advances in cancer detection and treatment have prolonged life expectancy in patients. Unlike the case with the phenomenon of bone pain in cancer, where current treatment strategies are not significantly effective. Most palliative treatment of bone pain are based on clinical studies on pain management in patients or in experimental models is not well designed this could explain why the drugs used are partially effective. Today, one of the main obstacles in developing new, safe treatments to control bone pain is the absence of basic science knowledge in the physiology of bone pain.

Epidemiology

The pain in cancer patients is usually multifactorial, may arise from the process itself, treatment side effects or both. For these reasons the approach and management of this symptom should be multidisciplinary. Pain syndrome occurs either by local proliferation or tumor invasion of a metastatic tumor from a distance. With metastatic bone pain often reflects the presence of a tumor in breast, thyroid, prostate, kidney, lung or adrenal.

Physiology of bone pain

Bone pain is associated with tissue destruction by osteoclast cells. Normally, osteoclastic bone resorption are in balance with bone formation mediated by osteoblasts. In neoplastic osteolytic activity is increased and there are substances such as cytokines, local growth factors, peptides similar to parathyroid hormone and prostaglandins. Autacoids are also released other owners as potassium ions, bradykinin and osteoclast activating factors. These tissue substances play an important role in sensitizing the neural tissue against chemical and thermal stimuli, lower thresholds for discharge of the neuronal membrane, produce exaggerated responses to stimuli above the threshold and result in discharges of tonic impulses normally silent nociceptors. This phenomenon is called peripheral sensitization and primary hyperalgesia and is understood as events occurring within the ranks of the injured tissue and stimulate peripheral nociceptors (C fibers and A delta fibers) translating pain. In bone tissue of the sensory receptors are located primarily in the periosteum, whereas the bone marrow and bone cortex are insensitive. This phenomenon of peripheral sensitization results in abnormal sensitivity to pressure surrounding skin (allodynia and hyperalgesia), pain in muscles, tendons, joints and deep tissues in contact with bone. This is limited to ensure that the peripheral ends have a greater capacity for alarm response to injury.

The constant presence of harmful process, stimulating nociceptive receptors gives the introduction of a subacute pain that tends to be chronic with the growth of bone metastases. These stimuli lead to another prevalent phenomenon called central sensitization important which includes abnormal amplification of incoming sensory signals to the central nervous system, particularly the spinal cord. The phenomenon occurs because of the persistent input stimulus through the fibers C. This spinal cord triggers a temporary increase in the power of silent synaptic terminals. In this process plays an important role of glutamate receptor N-methyl-D-aspartate (NMDA). The resulting amplification of the signal generated in the postsynaptic neuron sends a message to the brain which is interpreted as pain. In short central sensitization amplifies the sensory effects of both peripheral nociceptive inputs (C fibers of pain) and non-nociceptive fibers (A of touch).

In practice the two phenomena come together in the genesis of metastatic bone pain and peripheral sensitization occurs acutely metastatic lesions to appear nociceptors and translate the information conveyed through the afferent myelinated A-delta or unmyelinated C fibers to the spinal cord where the information is modulated by various systems. With the set up process subacute begins the process of central sensitization which sensory synapses begin to activate silent. And there is a state of increased central perception. By becoming chronic pain phenomenon becomes even more complex because all that is in contact with the area of injury becomes a powerful generator of pain. The touch, muscle movement or joint pain result, manifesting the phenomena of allodynia and hyperalgesia much more marked.

With progression and growth of metastatic disease can appear phenomena of compression of peripheral nerves, nerve roots or spinal cord. Then the pain can refer to other dermatomes, further complicating the initial picture painful. This condition becomes a debilitating factor for the patient and to be inadequately controlled could trigger the phenomenon of total pain detailed below.

I M Currently doing my doctorate and felt immense need to help the people about the Bone Cancer

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